tamoxifen dental side effects PLD can occur as isolated disease in autosomal dominant polycystic liver disease ADPLD, a rare liver disease with a prevalence of 1 158 000 1, 4, 5, but it is also the most common extrarenal manifestation of autosomal dominant polycystic kidney disease ADPKD, which has a prevalence of 1 400 1 2500 5 7